ASSESSMENT OF Tp-e INTERVAL, Tp-e/QT, Tp-e/QTc RATIOS IN THALASSEMIA MAJOR PATIENTS

Aim: Thalassemia major (TM) is a genetic hemoglobinopathy that causes chronic hemolytic anemia. Repeated blood transfusions are needed for treatment. Iron accumulation used to predict the risk of ventricular arrhythmia. We designed this study compare Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio, which novel reliable predictors show repolarization, between TM patients healthy control group.Method: included 97 who presented our outpatient clinic routine cardiac check-up from March 2019 June 2020 90 volunteers. In addition demographic echocardiographic findings, patients’ electrocardiograms (ECG) were retrospectively analyzed. Their serum ferritin, C reactive protein (CRP) levels neutrophil lymphocyte ratios recorded compared.Result: The interval was 80 msn (60.0-80.0) in group thalassemia whereas it 60 (50.0-70.0) (p<0.001) group. 0.200 (0.160-0.225) while 0.175(0.150-0.210) (p=0.014). 0.180 (0.130-0.190) 0.150 (0.130-0.180) (p=0.035). No correlation found their ferritin ECG parameters.Conclusion: Prolonged ve on associated with impaired repolarization due excessive iron deposition arrhythmias. These simple but parameters can be